ワークショップ抗血清におけるHLA特異性の検討
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概要
- 論文の詳細を見る
The First Japanese HLA workshop will be held in Chiba city in April 1976, in order to standardize the HLA typing sera and HLA typing techniques. About 180 local HLA typing sera were exchanged among 10 laboratories from Japan and Dr. Terasaki's laboratory from Los Angeles, U.S.A. prior to the workshop. Each workshop sera were tested against local pannels consisting of about 50 donor lymphocytes using the standard microlymphocyte cytotoxicity test in each laboratory. All data from workshop sera were sent to Dr. Terasaki's laboratory and analyzed by a computor at University of California, Los Angeles. These data will be discussed at the workshop and published as a Joint Report of the First Japanese HLA workshop in the near future. In this communication, the reactions of each workshop sera against our local lymphocyte pannels were presented in detail. The associations between the workshop sera and our standard HLA typing sera consisted of 12 HLA specificities in A locus and 15 HLA specificities in B locus calculated by Fisher 2 × 2 table method were also presented. In our local lymphocyte pannels, HLA-A 1, A 8, AW 29 and AW 32 antigens in A locus and HLA-B 8, BW 14, BW 16, BW 17, BW 18 and BW 27 antigens in B locus did not exist. A variety of reaction patterns were observed even among the workshop sera which were assumed to belong to the same HLA specificities. However, a small number of workshop sera showed good correlations with some standard HLA typing sera, for example, HLA-A 2, A 9, A 10 in A locus and HLA-B 5+BW 35, BW 15, BW 22 and BW40.
- 札幌医科大学の論文
- 1976-12-30
札幌医科大学 | 論文
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