肺癌患者の細胞性免疫に関する研究 ―とくにSarcoidosisおよび肺結核との対比―
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概要
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In recent years there has been cumulative evidences suggesting that depression of cell mediated immunity occurs in patients with lung cancer. It has been postulated that this depression of cellular immunity permits the accelerated growth of the tumor. It is also known that cellular immunity is depressed in a number of conditions other than cancer, of which sarcoidosis is the most outstanding example. In the present report, the conditions of cellular immunity were studied in 38 cases of lung cancer and were compared with those in 12 cases of sarcoidosis, 148 cases of pulmonary tuberculosis and 51 cases of the other pulmonary diseases. The effects of sera from these cases on cellular immunity were also studied and isolation of the inhibitory factors of the sera was attempted. The response of the lymphocytes from the patients with lung cancer to PHA was depressed in the presence of autologous serum as compared with that of controls. The response of lymphocytes from the patients with sarcoidosis was also depressed. However, no depression of the response was found in patients with pulmonary tuberculosis. On the other hand, the blastogenesis of normal lymphocytes to PHA was inhibited by the addition of sera from the patients with lung cancer into the culture medium. The addition of sera from the patients with sarcoidosis also inhibited the blastogenesis of normal lymphocytes. On the basis of these results, isolation of the serum factors responsible for the suppression by lymphocytes blastogenesis was performed by means of DE-52 column chromatography in order to elucidate the mechanism of the suppressive activities of the serum factores. The acidic α2-macroglobulin in serum was related to the suppressive activity of the cellular immunity in patients with lung cancer and the mechanism of the suppressive activity seemed to differ from that of sarcoidosis and tuberculosis.
- 1982-12-01
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