腸閉塞の病態に関する実験的研究
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概要
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In order to investigate the pathophysiology of various intestinal obstructions, the author induced experimental obstructions in 40 rabbits, divided into three different groups : a simple obstruction group, a strangulated obstruction group and a superioer mesenteric artery obstruction (SMAO) group. In the first experiment, the levels of plasma histamine, serotonin and endtoxin were deter- mined. In the second experiment, the intraluminal pressure of 30cm of water caused the endotoxin to seep through the wall of the intestine. Plasma endotoxin was then measured using MCA-sub- strate (peptide-4-methylcoumarin amide). The conclusions are summarized as follows ; (1) No changes were found in the levels of plasma histamine in any of the intestinal obstruction groups. (2) An increase in the plasma serotonin levels in all groups was found, especially in the SMAO group where the highest level of serotonin was found. (3) In all groups the levels of portal vein endotoxin gradually increased. However, the levels of plasma endotoxin in peripheral blood did not increase. (4) There was much to suggest that the portal vein endotoxin levels correlated with the plasma serotonin levels in the simple obstruction group and the SMAO group. (5) There was a marked increase in the levels of aerobic and anaerobic organisms in the closed loop of the experimental group. (6) The level of endotoxin that seeped through the intestinal wall showed and increased three hours after the operation began. The author has concluded from these results that a marked increase in the level of portal vein endotoxin will also increase the level of serotonin. This toxemic change will thus cause those rabbits with intestinal obstructions to die.
- 札幌医科大学の論文
- 1982-02-01
札幌医科大学 | 論文
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