実験的ハムスター舌癌形成過程の超微形態学的研究　III. 癌形成期における角化形態の変化について

概要

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ingual carcinomas induced by 9, 10-dimethy1-1, 2-benzanthracene (DMBA) were studied by electron microscopy with particular regard to the abnormal keratinization of cancer cells. Ultrastructurally, cancer cells revealed the following features ; marked dilatation of intercellular spaces, decrease or disappearance of desmosomes, large and irregularly shaped nuclei with prominent nucleoli, nuclear bodies and diffusely distributed chromatin, clustered ribosomes in the cytoplasm, many lysosomal bodies, increase in the number of keratinosomes in the cytoplasm, appearance of abnormal keratohyalin granules and intracytoplasmic desmosome like structures. Decrease in the number of tonofibrils was generally observed. It was noted that the correlation of development between tonofibrils and cell organelles, especially ribosomes, was often reversed, suggesting disturbed coordination among cell organelles in the cancer cell. Three kinds of dyskeratotic cells were seen ; those with an aggregation of tonofibrils around the nucleus similar to the "crown of thorn-like pattern" reported by Setala et al., individually keratinized cells, and cells with ingested dyskeratotic masses. Since some of these features were already observed in the epithelium of diffuse and papillomatous proliferation, it was considered that these ultrastructural characters seen in carcinomas were acquired step-wisely with the progress of carcinogenesis.
札幌医科大学の論文
1979-04-02