Cognitive Signals in the Primate Motor Thalamus Predict Saccade Timing
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We often generate movements without any external event that immediately triggers them. How the brain decides the timing of selfinitiatedmovements remains unclear. Previous studies suggest that the basal ganglia–thalamocortical pathways play this role, but thesubcortical signals that determine movement timing have not been identified. The present study reports that a subset of thalamic neuronspredicts the timing of self-initiated saccadic eye movements. When monkeys made a saccade in response to the fixation point (FP) offsetin the traditional memory saccade task, neurons in the ventrolateral and the ventroanterior nuclei of the thalamus exhibited a gradualbuildup of activity that peaked around the most probable time of the FP offset; however, neither the timing nor the magnitude of neuronalactivity correlated with saccade latencies, suggesting that the brain is unlikely to have used this information to decide the times ofsaccades in the traditional memory saccade task. In contrast, when monkeys were required to make a self-timed saccade within a fixedtime interval after an external cue, the same neurons again exhibited a strong buildup of activity that preceded saccades by severalhundred milliseconds, showing a close correlation between the times of neuronal activity and the times of self-initiated saccades. Theresults suggest that neurons in the motor thalamus carry subjective time information, which is used by cortical networks to determine thetiming of self-initiated saccades.
- Society for Neuroscienceの論文
- 2007-10-31
Society for Neuroscience | 論文
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