Accuracy and prognostic impact of a vessel invasion grading system for stage IA non-small cell lung cancer.
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概要
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BACKGROUND: Despite the recognition that lymphatic and blood vessel invasion is an important prognostic factor in lung cancer, there is no common definition for pathological evaluation of vessel invasion. The aim of the present study was to determine whether D2-40 immunostaining can increase the accuracy of detection of lymphatic vessel invasion and whether our new grading system of vessel invasion by "degree" could be used instead of conventional evaluation by "presence" for pathological stage IA non-small cell lung cancer (NSCLC). METHODS: The vessel invasion classification was re-evaluated in 221 recent paraffin-embedded sections of p-stage IA NSCLC stained by Hematoxylin-Eosin (HE), Elastica-Van-Gieson (EVG), and D2-40. RESULTS: After re-assessment using D2-40 immunostaining, 41.2% (31 of 75) of ly1 cases by HE/EVG changed to ly0, and 14.9% (17 of 114) of ly0 cases by HE/EVG changed to ly1. Overall, 4 of 28 ly2 cases on conventional staining were changed to ly1, and 2 were changed to ly0 using D2-40 immunostaining. When the patients were divided into two groups by the presence of vessel invasion (v/ly0 vs. 1, 2, 3), there was no significant difference in cancer-specific survival (p=0.1107, 0.0875, respectively), while when they were divided according to degree of vessel invasion (v/ly0, 1 vs. 2, 3), there was a statistically significant difference (p=0.0038, p=0.0002, respectively). On multivariate analysis, lymphatic vessel invasion had a significant impact on cancer-specific survival (p=0.0061). CONCLUSION: Our results suggest that D2-40 immunostaining provides a precise diagnosis of lymphatic vessel invasion, and our new grading system of vessel invasion by "degree" is accurate and has prognostic value in early lung cancer.
論文 | ランダム
- 街路・防犯照明における顔の見え方と照明レベル
- 4) 道路交通信号灯の所要条件(〔テレビジョン方式・回路研究会(第93回)視覚情報研究会(第62回)画像処理・画像応用研究会(第68回)〕合同)
- リハビリテーション概念の再検討(重複障害児部門,青年期の教育,部門別シンポジウム,日本特殊教育学会第五回大会発表抄録)
- 問題提起 : とくに研究方法をめぐって(精神薄弱児の人格形成)
- 問題提起 : とくに研究方法をめぐって(2.精神薄弱児の人格形成,シンポジアム)