Primary Malignant Fibrous Histiocytoma of the Pancreas : an immunohistochemical study

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A case of malignant fibrous histiocytoma (MFH) which arose in the pan-creas head is presented. Only 4 cases have been documented in the world litera-ture(1-4). An 86-year-old woman who had chronic congestive heart failure showed signs of anemia and an occasional tarry stool. Computed tomography and ultrasonography indicated the existence of a tumor which was located around the pancreas and suggested invasion to the duodenum. Postmortem examinations revealed a pancreas head tumor which had a cen-tral cystic area containing a muddy-like material and blood. Invasion of the tumor to the duodenal wall was observed and the connection between the duodenal cavity and the central cystic area of the tumor was also demonstrated. The histological appearance was that of a fine fibrous tissue showing a stor-iform pattern. Immunohistochemical features also supported the histiocytic cell origin.