MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma
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概要
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The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.
論文 | ランダム
- 事始め, あれこれ
- 新しい複合ワイヤ溶射法の開発と環境対応皮膜作製への応用
- 撥水機能と光触媒機能を有する粒子分散型溶射皮膜の開発 (溶射特集号)
- 103 撥水性および光触媒作用を有する溶射皮膜の開発(表面改質)
- ライムケーキの低温固化と調湿機能の評価