Analysis of the Metabolic Changes in pH, [HCO3-] and Pco2 in Blood Plasma at Steady State in vivo
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概要
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Previously we analysed [HCO_3^－] in blood plasma, by dividing it into a respiratory component, [HCO_3^－]^*, and a metabolic component, [HCO_3^－]^o. Assuming [HCO_3^－]^o to be independent of Pco_2, an exponential function of Pco_2 was obtained for [HCO_3^－]^*. More recently, we found, through regression analysis of the difference in pH from 7.4, that the metabolic component of pH－7.4, designated by pH－pH^*, could be evaluated by using the ratio [HCO_3^－]^o/[HCO_3^－]^*, and that this ratio, not the value for [HCO_3^－]^o, was independent of Pco_2. [HCO_3^－]^o at pH = 7.4, designated by s[HCO_3^－]^o, was calculated to test the validity of [HCO_3^－]^*, the regression functions of [HCO_3^－]^o and s[HCO_3^－]^o in venous blood, against those in arterial blood, were then calculated. Both the correlation and regression coefficients were close to unity, though the regression coefficient of [HCO_3^－]^o was slightly higher than that of s[HCO_3^－]^o. Further, in arterial and venous blood, the regression lines of pH and Pco_2 against s[HCO_3^－]^o were obtained in a number of acidotic and alkalotic patients, and the change in Pco_2, compensating for pH, was quantified. Designating [H^+] in normal blood, where s[HCO_3^－]^o = 0, by [H^+]^*, the ratio [H^+]/[H^+]^* was obtained in a number of anemic patients to check the effect of the hemoglobin concentration [Hb] on the metabolic change in pH. [H^+] agreed well with [H^+]^*, and no significant effect of [Hb] on the metabolic change in pH was found. Keywords：Acid-base imbalance, Components of [HCO_3^－], Change in pH, Metabolic change in Pco_2, Hemoglobin concentration.
- 2007-08-15
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