Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
Background/Aims: Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD). It has been reported that administration of mizoribine, an effective immunosuppressant, ameliorated renal fibrosis in a rat model of unilateral ureteral obstruction. We therefore examined the effects of mizoribine in an experimental model of peritoneal fibrosis. Methods: 24 rats were given a daily intraperitoneal injection of chlorhexidine gluconate and ethanol dissolved in saline. The rats were divided into three groups (n = 8 per group) that received either vehicle or mizoribine at a dose of 2 or 8 mg/kg once a day. 28 days after the start of the treatments the rats were sacrificed and peritoneal tissue samples collected. Macrophage infiltration (ED1), myofibroblast accumulation (alpha-smooth muscle actin (SMA)) and expression of type III collagen, transforming growth factor (TGF)-beta and monocyte chemotactic protein-1 (MCP-1) were examined by immunohistochemistry. Results: Mizoribine significantly suppressed submesothelial zone thickening and reduced macrophage infiltration. Mizoribine also reduced collagen III+ area and decreased the number of alpha-SMA(+), TGF-beta(+) and MCP-1(+) cells. The magnitude of the changes observed was dose-dependent. Conclusion: The administration of mizoribine prevented the progression of peritoneal fibrosis in this rat model. Mizoribine may represent a novel therapy for peritoneal sclerosis in patients undergoing long-term PD.
論文 | ランダム
- 内視鏡手術とナビゲイション
- 顔面痙攣患者における経頭蓋磁気刺激長潜時反応による顔面神経核の機能評価
- DISTRIBUTION AND COLD HARDINESS OF CHYMOMYZA COSTATA (ABSTRACT) (16th Symposium on Polar Biology)
- 束ねた複合磁気ワイヤの誘起電圧と周波数特性
- 複合磁気ワイヤの反磁界を利用した発電素子