Immunogenicity of slowly sedimenting antigen of Japanese encephalitis virus envelope glycoprotein isolated from infected culture fluids
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概要
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Slowly sedimenting antigen (SE) and the rapidly sedimenting antigen (RE), associated with envelope glycoprotein E were prepared from the concentrated infected culture fluids of Japanese encephalitis (JE) virus. Mice were immunized by each antigen before and after inactivation of virus infectivity by ultraviolet (UV) irradiation. The immunogenicity of the antigens determined by the plaque reduction neutralization test (PRNT), indirect ELISA and hemagglutination-inhibition (HI) test, indicated that SE was almost equally immunogenic as RE, and that the PRNT epitopes on both antigens were more immunogenic before UV -inactivation than after the inactivation.
- 日本熱帯医学会の論文
日本熱帯医学会 | 論文
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