SUSCEPTIBILITY OF VARIOUS CELL LINES TO RABIES VIRUS

概要

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7株のマウス由来組織培養細胞株を含む12の細胞株と初代鶏胎児細胞について，狂犬病ウイルスに対する感受性を検討した結果，これまで報告のあったCER細胞ならびにBHK-21細胞の他に，マウス神経芽細胞腫およびヒト神経芽細胞腫(SYM細胞)由来の細胞が，狂犬病ウイルスの固定毒ならびに街上毒に高い感受性を示し，マウスおよびヒトにおける狂犬病の研究，特に，組織適合抗原の適合性が重要な免疫学的研究に，これらの細胞が非常に有用であることが示唆された。Twelve established cell lines including 7 mouse-derived cell lines and primary chick embryo fibroblast cells were examined for their susceptibility to rabies virus. The results indicated that, in addition to CER cells and BHK-21 cells, murine neuroblastoma cells and human neuroblastoma cells (SYM cells) are highly permissive to infection with both fixed and field rabies strains and suggested the usefulness of these neuronal cell lines in various immunologic aspects of rabies studies in which histocompatibility requirements playa significant role.
1979-12-15