Streptococcus intermediusの感染に関与する付着機構

概要

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The first step of bacterial infection is adherence to host tissue. Streptococcus intermedius is a significant component in the normal oral floor and one of the most common causes of oral and systemic pyogenic infections. This organism possessed particular-type fimbriae expanded from the cell surface. Molecular biological approach demonstrated that the appendages were associated with bacterial aggregation and adherence mediated by human saliva. Receptor molecule on the host was purified and identified with saliva agglutinin/DMBTl/gp-340 from whole saliva. However, bacterial aggregation titer was not directly associated with adherence titer nor clinical data concerning dental caries among five healthy male. Thereafter, the molecule that inhibited the bacterial adherence to immobilized saliva agglutinin was identified with human albumin in human saliva. In the high concentration conditions, albumin worked as inhibitor, but in the low concentration conditions, as enhancer. The functional domain was located within the area from third exon to sixth exon using a valiant albumin clone derived from human fiver. The concentration of agglutinin and albumin in whole saliva was widely varied among individuals. These molecules could carefully control the composition of oral flora in individuals. I expect that further research could produce a novel and effective preventive approach for bacterial infection in systemic disease as well as oral disease.
2008-03-26