Quantitative comparison of fungi genomes performed by μTGGE genome profiling

概要

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Owing to diversities of phenotypes, fungi are one of the most intimately studied organisms and very popular among all. Micro-TGGE genome profiling, a newly introduced approach for genomebased identification of species which random-samples portions of genome DNA and extracts sequence-derived information by J.1 TGGE was applied to provisional identification of fungi and shown to be convenient, effective and reproducible. Quantitative analysis of the similarity between species in terms of PaSS (pattern similarity score) revealed that fungi were, unexpectedly, closely related with each other when viewed froIn the genome sequence. This IllUSt be the first result, for all organisms, obtained by quantitatively comparing genomes among more than 10 species at the order taxon level. It was discussed that since genome profiling does not require an immediate intervention of experts, this approach will allow general scientists as well as well-trained experts contribute to the progress of science through accumulating novel findings on fungi and other organisms with an aid of genome profiles.
埼玉大学工学部の論文