Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation
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概要
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Acute renal failure (ARF) is a common cause of mortality and morbidity in hospitalizedpatients. Ischemia is an important cause of ARF and ARF due to ischemic injury istraditionally referred to as ischemic acute tubular necrosis (ATN). There is growingevidence that ischemic ATN is associated with intra-renal inflammation using ischemicATN models. Consequently, intra-renal inflammation is an attractive target for thedevelopment of novel drug therapies for ARF. In this review, we will outline ischemicATN models, the pathophysiogical roles of inflammatory cells such as T and B cells inischemic ATN models, and effective T and B cell therapeutic reagents.
- Elsevier Scienceの論文
- 2006-04-00
Elsevier Science | 論文
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