カラ・アザール症の臨牀並びに催貧血性物質に關する實驗的研究
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概要
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Though kala-azar has been observed in Japan to such an extent that it may not necessarily be considered a rare disease, the etiological basis of its more conspicuous characteristics, viz. anemia and Banti's syndrome, has not been established. In the author's opinion the development of both the anemia and the Banti's syndrome may be closely associated with the splenomegaly which is so evident in kala-azar. Experimental studies were carried out by the author with the following results: 1. Clinical observations on ten kala-azar cases revealed that the leishmania disappeared form the sternal or splenic aspiration after one to two courses of pentavalent antimony in nine cases-one case having required treatment with stilbamidine. In addition the anemia was improving in parallel with the reduction in splenomegaly. 2. The serum of the kala-azar patient produces an anemia in rabbits. This anemia-producing action is demonstrable during the period of splenomegaly, but is not necessarily associated with the presence of leishmania organisms. This anemia-producing factor is thermostable and soluble in water, but, insoluble in ether and methyl, alcohol. 3. No such anemia-producing action is seen in the serum of the normal man or the cured kala azar patient. 4. The anemia-producing action can be demonstrated in the urine of the kala-azar patient but not in the urine of the normal man. 5. In the following group of diseases having anemia or splenomegaly as a characteristic, an anemia-producing substance can be demonstrated: anchylostomiasis with anemia, essential thrombopenia, and splenomegaly with Banti's syndrome. This substance has not been demonstrated in chronic nephritis, pernicious anemia, gastric cancer, gastric ulcer, myelogenous leukemia, anemia associated with dystrophy, anemia secondary to chronic tuberculosis of bone, splenic congestion, and splenomegaly without anemia.
- 千葉医学会の論文
- 1952-03-28
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