Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride
スポンサーリンク
概要
- 論文の詳細を見る
The influence of chronic hepatic failure on the disposition kinetics of valproate (VPA) excretion via a phase II reaction was examined in rats treated with carbon tetrachloride (1.0 mg/kg, s.c., 3 times a week) for 2 or 3 months. There was no significant difference in the plasma concentration-time courses of VPA among the control and two treated groups up to 120 min after i.v. administration of VPA (75 mg/kg), but subsequently the plasma concentrations of the treated groups declined significantly below the control levels. Expression of Mrp2 mRNA in the liver of the treated groups was significantly lower than in the control group; conversely that in the kidney was significantly higher. The enzyme activity of UGTs in the liver of the treated groups decreased significantly, but UGT1A8 mRNA expression in the duodenum was increased about 3-fold. Cumulative excretion of VPA glucuronide (VPA-G) in bile of the treated groups was reduced significantly, while that in urine was markedly increased. In conclusion, the area under the VPA plasma concentration-time curve was decreased significantly in rats with chronic hepatic failure owing to increased excretion of VPA-G via the kidney as a result of induction of Mrp2, and inhibition of enterohepatic circulation of VPA-G. Copyright © 2007 John Wiley & Sons, Ltd.
論文 | ランダム
- 知られざる「100年」プロジェクト 鞆の浦--危機に瀕する世界遺産
- 高齢者居住の現場訪問(8)高齢者を家族や地域につなげ、自然に見守る地域づくり--江戸時代の醸造家を改修した「鞆の浦・さくらホーム」
- 交流を生む戸外で行われる日常生活に関する研究 : 広島県鞆の浦における地域性と生活スタイルの変化を中心に(推薦理由,2003年日本建築学会優秀卒業論文賞)
- 7129 戸外で行われる日常生活の変容とその原因に関する研究 : 広島県鞆の浦でのケーススタディ(街路空間とその構成要素,都市計画)
- 「鞆の浦」の歴史的文化景観問題(1)「鞆の浦」の歴史的文化景観と埋立・架橋計画の交錯