ポリグラフによるDDT急性中毒時の症候と意味づけ
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概要
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Adult female guinea pigs and rabbits were used in the present study. Each animal was intraperitoneally injected with 1, 200, 800 or 400mg/kg of DDT emulsion in guinea pigs and 400, 300, 150, 120, 90 or 30 mg/kg in rabbits. Clinico-physiological variables in acute poisoning were measured by the use of polygraphic instrument. The heart rate was counted on the electrocardiogram recorded through the method of bipolar limb leads. The respiratory rate was calculated by the pneumotachogram in which the respiratory current was transduced electrically. The blood pressure was measured by the mercury manometer connected directly with the carotid artery. The rectal temperature was taken by the theromometer in guinea pigs. Electroencephalogram was recorded by the method of an unipolar- and bipolar-lead from the frontal lobe of the brain, electromyogram was taken by the use of coaxial needle electrode from the neck, intercostales, obliquus abdominis muscles and diaphragma, plus electrocardiogram was also recorded by the method of A-B lead in rabbits. The result obtained were as follows. 1. In the case of intraperitoneal administration, The LD₅₀ of DDT was about 400mg/kg for guinea pig and 120mg/kg for rabbit respectively. 2. Several minutes after DDT administration violent struggle, salivation and lacrimation were generally observed in the treated animal, being regardless of drug dosage and the animals was killed within 10 to 60 minutes. 3. The poisoning symptoms in guinea pigs were sudden decrease of the heart rate and respiratory rate. The blood pressure also declined abruptly. Although the heart rate in rabbits was expressed in the same fashion as that of guinea pigs, the respiratory rate changed differently, as shown a sudden rise to recover to premeditation value. 4. Major change in electrocardiogram, being due to DDT administration were heart beat irregularing, T wave inversion and atrial premature beats. Increase of activity in electromyogram of the intercostal muscle, the diaphragma and the abdominal muscle were observed at the same time. In electroencephalogram, the slow waves suppressed rapid waves and occasional seizure waves were presented.
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