Differential Withdrawal of Retinal Axons Induced by a Secreted Factor
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To understand the development of the topographic map in thechick retinotectal projection, we studied the long-term interactionsbetween retinal axons and tectal cell processes using anovel coculture system, the ryomen chamber. Both nasal andtemporal retinal axons initially grew equally well on a substrateconsisting of posterior tectal cell processes; however, subsequentlymost temporal axons withdrew from this surface,whereas most nasal axons did not. Experiments using conditionedmedia indicate that posterior tectal cells induced withdrawalof the temporal axons by secreting a soluble factor. Thiswithdrawal seems to be distinct from the immediate repulsiveeffect of ephrin-A2 (ELF-1) and ephrin-A5 (RAGS) seen in thestripe assay because (1) the withdrawal-inducing factor wasdiffusible, whereas ephrin-A2 and -A5 are membrane-bound,and (2) the withdrawal-inducing factor appeared later in developmentthan ephrin-A2 and -A5. Furthermore, sensitivity to thewithdrawal-inducing factor decreased continuously from thetemporal to nasal retina. These results suggest that targetcell-induced axonal withdrawal may be involved during a latestage of the development of the retinotectal map.
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