Role of LIM kinases in normal and psoriatic human epidermis
スポンサーリンク
概要
- 論文の詳細を見る
American Society for Cell Biology, Masaru, Honma ; Salvador Aznar, Benitah ; Fiona M. Watt, Molecular biology of the cell, 17(4), 2006, 1888-1896.We present evidence that LIM kinases can control cell adhesion and compaction in human epidermis. LIMK2 is expressed in the epidermal basal layer and signals downstream of the GTPase Rac1 to promote extracellular matrix adhesion and inhibit terminal differentiation. Conversely, LIMK1 is expressed in the upper granular layers and phosphorylates and inhibits cofilin. Expression of LIMK1 is lost in psoriatic lesions and other skin disorders characterized by lack of cell compaction in the differentiating cell layers. In psoriatic lesions down-regulation of LIMK1 correlates with up-regulation of Myc. Expression of constitutively active cofilin or Myc in reconstituted human epidermis blocks cell compaction. Overexpression of LIMK1 leads to down-regulation of Myc, whereas inhibition of Rho kinase, an upstream activator of LIMK1, stimulates Myc expression. Inhibition of Myc by LIMK1 is via inhibition of Stat3 phosphorylation, because constitutively active cofilin or inhibition of Rho kinase results in Stat3 phosphorylation and increased Myc levels, whereas dominant negative Stat3 abolishes the effect. In conclusion, we have uncovered a novel antagonistic relationship between the LIMK1/phosphocofilin and Myc/Stat3 pathways in the differentiating layers of human epidermis and propose that down-regulation of LIMK1 contributes to one of the pathological features of psoriatic epidermal lesions
論文 | ランダム
- 滑走路3,500メートルへ、新たな助成策も--新千歳空港が東京でプレゼンテーション
- 〔関西空港部会〕第72回研究会 新千歳空港および地域プロジェクト 見学会レポート
- あのヤジさん・キタさんもビックリ! 新しいサービスが加わりました--新千歳空港B駐車場にマイレージサービス…
- 駐車場紹介 冬の北海道 厳しさの中に使命感を持って--新千歳空港駐車場事情
- 里親制度 (特集 児童福祉法と虐待対応)