Cigrette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line
スポンサーリンク
概要
- 論文の詳細を見る
出版者ポリシー：機関リポジトリへの掲載不可.全文非公開.Rheumatoid arthritis (RA) is characterized by proliferation of synoviocytes that produce proinflammatory cytokines, which are implicated in the pathogenesis of RA. When human fibroblast-like synoviocytes line MH7A was treated with cigarette smoke condensate (CSC), either mainstream or sidestream, expression levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, and CYP1A1 mRNA were upregulated in both time- and dose-dependent manners. The upregulatory effects of CSC on these cytokines were not significantly inhibited by α-naphthoflavone, an aryl hydrocarbon receptor (AhR) antagonist, suggesting that the effects of CSC were independent of AhR. Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1α, IL-1β and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis. CSC also induced cytokines at protein levels and further augmented the effects of tumor necrosis factor α on induction of these cytokines at both mRNA and protein levels. These results support the epidemiological studies indicating a strong association between heavy cigarette smoking and pathogenesis of RA.
- 2008-08-01
論文 | ランダム
- 定延利之・中川正之編, 『シリーズ言語対照1音声文法の対照』 第1巻, 2007年6月5日発行, くろしお出版刊, A5判縦組み, 226頁, 3,000円+税, ISBN978-4-87424-383-1 / 西光義弘・水口志乃扶編, 『シリーズ言語対照3類別詞の対照』 第3巻, 2004年11月3日発行, くろしお出版刊, A5判横組み, 228頁, 3,000円+税, ISBN978-4-87424-313-8 / 益岡隆志編, 『シリーズ言語対照
- 琴平町の実践に対するコメント (地域福祉実践シリーズ 香川県琴平町の実践)
- つなぐ、つなげる、つながる (地域福祉実践シリーズ 香川県琴平町の実践)
- 地域福祉実践シリーズ 香川県琴平町の実践
- アンケート調査 景況感は足踏み状態--香川県内企業経営動向調査(平成22年9月実施)