Alymphoplasia mice are resistant to prion infection via oral route
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The major cause of infection in animal prion diseases is thought to be consumptionof prion-contaminated stuff. There is evidence that the entericnerve system (ENS) and gut-associated lymphoid tissues (GATL) are involvedin the establishment of prion infection through alimentary tract. To elucidatethe initial entry port for prion, we inoculated prion to alymphoplasia (aly )mice showing a deficiency in systemic lymph nodes and Peyer’s patches. Thealy ／aly mice were susceptible to prion infection by intra-cranial inoculationand there were no differences in incubation periods between aly／aly mice andwild-type C５７BL／６J mice. Incubation periods in aly／aly mice were about２０days longer than those in C５７BL／６J mice with the intra-peritoneal inoculation.The aly ／aly mice were completely resistant to prion infection by per osadministration, while C５７BL／６J mice were sensitive as they entered the terminalstage of disease around３００days post inoculation. PrPSc were detected inthe intestine and spleen of C５７BL／６J mice inoculated with prion intraperitoneallyor orally ; however PrPSc was not detected in the spleen and intestineof aly ／aly mice. Prion infectivity was detected in the intestines andspleens of prion-inoculated C５７BL／６J mice, even after the early stages of exposure,while no infectivity was detected in these tissues of prion-inoculatedaly ／aly mice. No apparent differences were observed in the organization ofthe enteric nerve system between wild-type and aly ／aly mice. These resultsindicate that GALT rather than ENS acts as the primary entry port for prionafter oral exposure.１）Laboratory of Prion Diseases, Graduate
- The Graduate School of Veterinary Medicine, Hokkaido Universityの論文
- 2006-02-28
The Graduate School of Veterinary Medicine, Hokkaido University | 論文
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