Lack of Association between Endoplasmic Reticulum Stress Response Genes and Suicidal Victims

概要

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As lithium has been shown to have a protective effect against suicidal behavior,genes on which mood stabilizers act may be involved in biological susceptibility tosuicide. A recent study showed that endoplasmic reticulum (ER) stress response wasimpaired in the bipolar disorders and the impairment was ameliorated by a moodstabilizer, valproate. We hypothesized that an alteration of ER stress response isinvolved in the biological susceptibility to suicide through genetic polymorphisms, andexamined the association of polymorphisms of X-box binding protein 1 (XBP1) andheat shock 70-kDa protein 5 (HSPA5) genes with suicide. We found no significantdifference in the distribution of these polymorphisms between the suicide victims andthe controls. These results suggest that the polymorphisms examined in this study arenot involved in the susceptibility to suicide of the Japanese.
神戸大学医学部の論文
2007-08-00