皮膚の誘電率変化を利用した薬物の経皮吸収促進法

概要

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Over the years, extensive research effort has been devoted to the development of noninvasive drug delivery techniques for controlled systemic delivery of therapeutic peptides and proteins through various easily accessible tissues. Iontophoresis has recently been discovered as a potential drug delivery technique for noninvasive, programmed systemic delivery of peptide and protein drugs. In this paper, the feasibility of using iontophoretic delivery devices to facilitate the transdermal transport of some drugs across the skin is demonstrated. In vivo pharmacokinetics and pharmacodynamic studies in diabetic animals suggested that the systemic bioavailability of peptides and proteins are dependent upon the electronic variables of the iontophoretic delivery device, e.g. frequency, on/off ratio and intensity of the current applied, physiochemical parameters. The mechanism of iontophoresis transdermal transport of peptide macromolecules are analyzed.
関東学院大学工学総合研究所の論文