Response of Serum Prolactin to Thermal Stress During Water Immersion

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Physiological action of prolactin is not well-known in human except those concerning pregnancy and lactation. Elevated serum prolactin level due to various stresses such as heat load, physical exercise, surgery, gastroscopy has been reported. In order to elucidate the response of serum prolactin to thermal stress, preliminary experiments were done in a male subject. Three different thermal stimuli were applied by head-out water immersion (water temperature: 28.5, 34 and 40℃, respectively) for 30 or 60min. Decrease of 1.5℃ in oral temperature and 48% decrease of serum prolactin concentration compared to basel level were induced by 28.5℃ water immersion. Decrease of 0.6℃ in oral temperature and almost stable prolactin level were observed during 34℃　water immersion. By 40℃ water immersion, 2.1℃ increase in oral temperature and 578% increase of prolactin level were induced. And in every experiment, prolactin level returned to control level (5-13ng/ml) 24 hours after cessation of thermal stimuli. Highly significant correlation of mean body temperature with serum prolactin level was observed at the different thermal stimuli. The present results indicate the thermo-dependent regulatory mechanism of prolactin release in human.
長崎大学熱帯医学研究所の論文
1988-12-28