Effect of Thermal Acclimation on Change in Cerebral Blood Flow during LPS-pyrogen Fever in Rabbits

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Local blood flow in the hypothalamus (BFhy) and the reticular formation in the midbrain (BFrf) in fever induced by lipopolysaccharide (LPS-pyrogen: 3μg/kg i. v.) were measured by the hydrogen clearance method together with respiratory rate (RR), rectal (Tre), hypothalamic (Thy) and ear skin (Tea) temperatures in rabbits exposed to normal (25℃), heat (30℃) and cold (10℃) temperature for 4 weeks. BFhy and BFrf were analyzed till 100 min after LPS-pyrogen injections during the early phase in fever. In normal acclimated rabbits: (1) Mean of Tre, Thy, Tea, RR, BFhy and BFrf just before the injection of LPS-pyrogen were 38.93±0.12℃, 38.55±0.14℃, 30.5±1.1℃, 106±7 min^<-1>, 36.84±2.11ml/100g/min and 35.62±3.10ml/100g/min, respectively. (2) BFhy and BFrf significantly increased with increase in Tre and Thy during fever. (3) There were no significant difference between BFhy and BFrf and between Tre and Thy before and during fever. (4) Correlations among BFhy, BFrf, Tre and Thy were statistically significant. (5) In heat and cold acclimated rabbits, BFhy and BFrf hardly increased during fever. The increase in BFhy and BFrf is considered to have useful effects in the process of fever, because the endogenous pyrogen and the thermal signals of core temperature are speedily transported to the brain by bood circulation.
長崎大学熱帯医学研究所の論文
1992-03-21