急性下痢腸炎の病理

概要

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An acute enteritis with severe diarrhea is an important as well as an interesting disease for pathology. At first we reported the characteristic pathological changes, which are found in the intestinal wall of El tor cholera patients and cholera nostras caused by Salmonella typhimurium, and then discussed the mechanism of severe diarrhea. 1) Pathological changes which are found in the intestinal wall of an acute enteritis characterized by severe diarrhea such as El tor cholera and cholera nostras is revealed histologically to an acute enteritis accompanied with blunting, shortening and fusing of intestinal villi. 2) It was proved histometrically and experimentally that shortening, blunting and fusing of intestinal villi are not characteristic of chronic pathologic process as seen in spruelike syndrome, but they appear also in an acute enteritis accompanied with severe diarrhea. 3) Surface area of the intestine of cholera patient is quantitatively reduced untill 1/2-1/4 of a normal case due to shortening, blunting and fusing of intestinal villi. 4) There were large amount of amylase, lipase and tryptic activity in many cases of cholera stool. This observation suggested that large quantity of liquid must be derived from digestive apparatus in upper abdomen.
長崎大学熱帯医学研究所の論文