Metronidazoleとtinidazoleが効果を示さず多量のシストを排出し免疫反応が陰性であったアメーバ赤痢の二症例

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Two cases of amoebic dysentery with ineffectiveness of metronidazole and tinidazole were reported. Patients were admitted to the hospital because of diarrhea and protein loosing enteropathy. The patient of the first case was a 73-year-old man who has had diarrhea of several watery stools with mucus every day for 9 months before admission into the hospital. He has never been abroad for 9 years from 1973, and had no trouble previously. As a large number of Entamoeba histlytica cysts were found from his stool, tinidazole 2.0 g/day and metronidazole 1500mg/day were given to him. Despite these treatments the number of cysts in stools did not decrease and his symptoms did not change. Therefore, dehydroemetine 45 mg/day was given for 10 days. After this treatment, the cysts of amoeba disappeared in the stool and amount of serum protein increased to the normal level without supply of albumin. The second case was a 23-year-old woman, who lives near the first patient. She has never been outside of Japan, and she has already noticed the distribution of the mucus and blood in her stools at 18 years of age, when E. histolytica cysts had been found at the examination of stool and metronidazole was prescribed for her, but her symptoms did not improve. Metronidazole and tinidazole were given again at age 23, because the abdominal pain and fever became severe for 2 months. As the symptoms continuied, dehydroemetine 60 mg/day was given for 10 days. After this treatment, the abdominal pain disappeared and mucus and blood decreased in the stool. Immunological examination was carried out with Ouchterlony's doublediffusion test using three strains of E. histolytica as antigen. Reactions of the sera of both patients were all negative.
長崎大学熱帯医学研究所,Institute of Tropical Medicine, Nagasaki Universityの論文
1984-06-30

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牧山和也
日本消化器内視鏡学会内視鏡部設置検討委員会

Metronidazoleとtinidazoleが効果を示さず多量のシストを排出し免疫反応が陰性であったアメーバ赤痢の二症例

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