肝生検によるカラ・アザールの病理形態

概要

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Histopathological study of Kala-azar using liver biopsy was done. The patient was a 19-year-old African of Trukana tribe. He had emaciation, hepato-splenomegaly and hyperglobulinemia. Microscopic examination of biopsy specimen of the liver revealed marked infiltration of plasma cells, lymphocytes and macrophages mainly in the portal areas. Among these cells, plasma cells were most prominent. Therefore, the plasma cell is likely to be one of the main reactive cells in Kala-azar. Leishman-Donovan bodies were found mainly in macrophages in portal areas and in Kupper's cells in lobules. However, they could also be seen in parenchymal cells in some parts of the liver. Characteristic intracellular organelles of the protozoa, such as nucleus, kinetoplast and axoneme were found by electron microscopic examination. Therefore, this protozoa was confirmed to be in the amastigote stage. Histopathological differences of Kala-azar from chronic active hepatitis and histoplasmosis were also discussed.
長崎大学熱帯医学研究所の論文
1979-11-30