Relationship Between Eosinopenic Response to Cold Application and the Adrenal Gland in the Dog

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The dogs were immersed into the ice water for periods of 18-55 minutes. Following withdrawal from the ice water bath, peripheral blood was sampled at an interval of 30 minutes for 5-8 hours and was used for the eosinophil counts. Bilateral adrenalectomy was performed on dogs without anesthesia. The right adrenal gland had been extirpated about 4-20 days before and the left gland at the day of observation. Cold application induced a profound fall in the number of the circulating eosinophils of the intact and of the chronically adrenal demedullated dog, its lowest level being noted within approximately 2-4 hours after the withdrawal. However, the adrenalectomized dog exhibited no or only a slight and transient fall in the eosinophil levels following cold application. Our results seem to warrant the conclusion that the eosinopenic response of the intact dog to cold application is, in the major part, due to the increased adrenal cortical activity.
Nagasaki University School of Medicineの論文
1962-03-00