Structural characterization of phosphatidylcholine-diacylglycerol system by neutron scattering and X-ray diffraction
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概要
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Diacylgylcerol(DAG) is recognized one of the most important lipids for biological functions of cell membranes. In order to understand the functions of DAG, it is indispensable to study the effect of DAG on phosphatidylcholine(PC) which is a main lipid component of biomembranes. Here we report neutron scattering data of sonicated PC/DAG vesicles and X-ray diffraction data of oriented PC/DAG multilamellar systems. These data imply that addition of DAG induces the change in the tilt angle of lipid molecules and that, as a result, the increase of the membrane thickness is induced. Previous study [6], to make clear this point, the analysis of X-ray intensity data has been performed by assuming a model of electron density distribution of the system. As a result, it has been suggested that addition of DAG thickens the membrane bilayer. In this study, using sonicated vesicle and oriented multilamellar samples, we reexamined the PC/DAG systems by means of neutron scattering and X-ray diffraction, paying attention to the effect of DAG on the PC bilayer structure.
- Springerの論文
Springer | 論文
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