The Effects of One-Lung Venttilation on Cytokine Production from Lung Tissue of Rat Is One-Lung Ventilation Reasonable for Thoracic Surgery?

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We hypothesized that the collapsed lung during one-lung ventilation would be a main sourse of cytokine production. Rats were randomly assigned to 3 groups: control rats (C group) (n=10); one-lung ventilation rats (OLV group), ventilated after left thoracotomy (n=10). We measured interleukin (IL)-6 IL-10, and growth related oncogene/ cytokine-indused neutrophil chemoattractant (GRO/CINC)-1 level in supernatants of lung tissue incubared for 6 hours. In the left lung (thoracotomy side), althouth IL-6 and IL-10 level from collapsed lung in the OLV group was lower than that in the OLV group was higher than that in the Cgroup, GRO/CINC-1 level was not. IL-6 and GRO/CINC-1 level from collapsed lung in the OLV and TLV groups was higher than that in the Cgroup, but IL-10 level did not change. With regard to balance of inflammatory and anti-inflammatory cytokine production, a complately collapsed lung on the thoracotomy side. One-lung ventilation appears to be reasonable for thoracic surgery.