Boron distribution in the normal rat brain after intravenous injection of boronophenylalanine-fructose
スポンサーリンク
概要
- 論文の詳細を見る
Boron neutron capture therapy (BNCT) is an experimental form of radiation therapy for malignant brain tumors and peripheral melanoma. The micro-distribution of the boron compound is critical to determine the radiation effects for both tumors and normal tissue. In the current dose calculation of BNCT, normal brain tissue is considered to have a homogeneous boron concentration. The purpose of this study was to examine the structure-specific boron concentration in normal rat neural tissue. At 10, 30 and 60 min after intravenous injection of 300 mg/kg boronophenylalanine-fructose to 10-week-old CD Fisher rats, neural tissue and blood were collected. Various neural structures were anatomically and histologically identified and specific boron concentrations were analyzed using high-resolution quantitative autoradiography. At 60 min after the injection, only the pituitary gland showed a higher boron concentration than that in blood, with the former being threefold higher. All other neural structures showed lower boron concentrations than that in blood. The present study thus demonstrated an extremely high boron concentration in the pituitary gland following intravenous injection of boronophenylalanine-fructose. In clinical trials of BNCT using an epithermal neutron beam, the radiation dose to the pituitary gland should be carefully evaluated.
論文 | ランダム
- 枕草子の祝祭的時空--「供犠」としての翁丸 (古代文学と宮廷)
- 2, 3-ジアミノプロピオン酸をキャリアとする含浸液膜によるCO_2の促進輸送
- 含水ゲルを利用した促進輸送膜によるモデル排煙中のCO_2の分離
- 断層模型実験:基盤の変位に対する被覆層のレスポンス
- 阿武隈山地広野地域の地質構造