Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice
スポンサーリンク
概要
- 論文の詳細を見る
We have recently demonstrated that naphthoquinone (NQ), one of extractable chemical compounds of diesel exhaust particles (DEP), enhances antigen-related airway inflammation with goblet cell hyperplasia in mice (Inoue et al. in Eur Respir J 209(2):259–267, 2007). Further, NQ has enhanced lung expressions of interleukin (IL)-4 and IL-5. However, the effects of NQ on other cardinal features of asthma have not been completely investigated. The aim of the present study was to evaluate the effects of NQ on airway responsiveness on the model. Vehicle, NQ, ovalbumin (OVA), or NQ + OVA was administered intratarcheally to ICR mice for 6 weeks. Twenty-four hours after the last instillation, lung histology, lung functions such as total respiratory system resistance (R) and Newtonian resistance (R n), and protein level of IL-13 and mRNA level for MUC5AC in the lung were examined. Repetitive exposure to NQ aggravated antigen-related lung inflammation. NQ alone enhanced R and R n as compared to vehicle without statistical significance. OVA alone or NQ plus OVA showed increases in R and R n, which was prominent in NQ plus OVA (P < 0.05 vs. vehicle). Combined exposure to NQ and OVA elevated the levels of IL-13 and MUC5AC in the lung as compared with exposure to NQ or OVA alone. These results indicate that NQ can enhance airway hyperresponsiveness in the presence or absence of an antigen. Also, amplified lung expressions of IL-13 and MUC5AC might partly contribute to the deterioration of asthma features by NQ.
論文 | ランダム
- 非癌胃粘膜,胃腺腫および胃癌内の嗜銀細胞
- 賛成するための留保条件を育てる (特集 「エネルギー問題」を授業化する) -- (誌上シンポジウム 提案に対する意見)
- セラミックエアスライド・エアスピンドル利用「超」高速・精密位置決めテ-ブル (特集 アルミナの動向)
- ジボラン吸入曝露による雄性ICRマウスの急性, 亜急性毒性および肺病変の経時的変化
- Immunolocalization of gastrolith matrix protein (GAMP) in the gastroliths and exoskeleton of crayfish, Procambarus clarkii