High Sodium Intake Strengthens the Association of ACE I/D Polymorphism with Blood Pressure in a Community
スポンサーリンク
概要
- 論文の詳細を見る
BackgroundLimited evidence is available on a gene–environment interaction of angiotensin-converting enzyme (ACE) gene I/D polymorphism and high blood pressure (BP) with salt intake among general populations. We hypothesized that persons with the I allele of the ACE gene have elevated BP levels in response to a higher sodium intake, and thus the association of ACE I/D polymorphism with BP levels was stronger among persons with a higher sodium intake than those with a lower sodium intake.MethodsWe conducted a population-based cross-sectional study of 2823 men and women aged 30 to 74 years in a Japanese rural community to examine the association of the ACE I/D polymorphism with BP levels stratified by salt intake, as estimated by 24-h urine collection and dietary questionnaire. Polymorphism of the ACE I/D was detected by an allele-specific polymerase chain reaction.ResultsThere was no significant difference in BP levels among DD, ID, and II groups for either sex or total samples. However, mean difference in diastolic BP levels for II versus DD groups was +3.0 mm Hg (P = .003) among persons with higher sodium excretion, +1.8 mm Hg (P = .04) among those with higher present sodium intake score, and +1.7 mm Hg (P = .06) among those with higher past sodium intake score.ConclusionsA high sodium intake strengthens the association of ACE I/D polymorphism with BP levels in community-based samples. Key Words: ACE; genetics; molecular epidemiology; salt sensitivity; gene–environment interaction; hypertension; sodium excretion; renin-angiotensin system
論文 | ランダム
- 29.本学屋内空気中に浮遊するStaphylococcusの菌種構成と薬剤感受性
- 皮膚Staphylococcusの菌種プロフィル菌種間における抗生物質耐性菌の分布
- 臨床分離Staphlococcusの薬剤感受性
- アクリジン化合物の変異原性と化学構造 : スポット法とプレインキュベーション法による変異活性の比較
- 水田土壌におけるセルロースの分解と土壌微生物群集