Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas.
スポンサーリンク
概要
- 論文の詳細を見る
Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples from tongue squamous cell carcinomas were analyzed semiquantitatively by immunohistochemistry. Correlations between the expression level of HO-1 and the clinical features of tumors were statistically analyzed. Fifty-four cases with surgical confirmation of lymph node metastasis were examined for the association between cervical lymph node metastasis (pN) and other clinical features, including the HO-1 expression level, using logistic regression. The low HO-1 expression group contained significantly more undifferentiated samples (P=0.04) and pN positive cases (P=0.01) by univariate analysis. The low HO-1 expression group (odds RATIO=8.49; 95% confidence INTERVAL=1.64–44.09, P=0.01) and an endophytic shape (odds RATIO=16.79; 95% confidence INTERVAL=1.77–159.53, P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary.
論文 | ランダム
- 最近の口腔外科手術と口腔再建-2-マイクロサ-ジャリ-による再建
- 14167 廃嘘を介した自然と建築の関係に関する研究(緑化,建築デザイン)
- 建築における空間の関係性の研究(建築作品)
- Isolation of 9Z β-Carotene from Dunaliella bardawil and Its Stereoselective Synthesis
- 7.心身医療と教育との連携についての検討 : 摂食障害との関係(第103回日本心身医学会関東地方会演題抄録,地方会抄録,学会報告)