胆道出血を契機に発見され，動注化学療法を行った肝細胞癌の1例

概要

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Case is 60 year-old-man who had been followed up about liver injury and diabetes mellitus in another clinic from 1990. He visited our hospital suffering from epigastralgia in October 2003, and admitted with the finding of hemobilia pointed out by upper GI examination. We diagnosed the illness as hepatocellular carcinoma with hemobilia, because of multiple tumors in the right lobe of the liver, portal vein thrombus, and the elevation of tumor markers such as alpha-fetoprotein (AFP), protein induced by vitamin-K absence (PIVKA-II) and AFP L3 fraction with alcoholic liver cirrhosis. He was treated with combination therapy consisting of hepatic arterial chemotherapy and injection of Interferon-ﾎｱ, and done as an outpatient after the first course treatment. The biliary infection was aggravated during the 4th course, and died 8 months after the initial diagnosis. It is said that hepatocellular carcinoma diagnosed incidentally with hemobilia is relatively rare and that prognosis is poor. In spite of the absence of decrease in tumor on imaging, this case can be considered as one in which this patient got the more prolongud life by interferon combined hepatic arterial chemotherapy.
日本肝臓学会の論文
2005-00-00