The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling
スポンサーリンク
概要
- 論文の詳細を見る
Cerebellar granule cell precursors (GCPs) proliferate in the outer part of the external granular layer (EGL). They begin their differentiation by exiting the cell cycle and migrating into the inner part of the EGL. Here we report that JSAP1, a scaffold protein for JNK signaling pathways, is expressed predominantly in the post-mitotic GCPs of the inner EGL. JSAP1 knockdown or treatment with a JNK inhibitor enhances the proliferation of cultured GCPs, but the overexpression of wild-type JSAP1 leads to increased proportions of p27Kip1- and NeuN-positive cells, even with saturating concentrations of Sonic hedgehog (Shh), a potent GCP mitogen. However, these differentiation-promoting effects on GCPs are attenuated significantly in cells overexpressing a mutant JSAP1 that lacks the JNK-binding domain. Together, these data suggest that JSAP1 antagonizes the mitogenic effect of Shh on GCPs and promotes their exit from the cell cycle and differentiation, by modulating JNK activity. © 2008 Elsevier Inc. All rights reserved.
論文 | ランダム
- ジャックスにおけるカード不正検知システムの導入と運用の実際--モデルの精度向上と運用体制の強化で高いパフォーマンスを確保
- R&I格付け JALグループ、旭硝子、三井化学、東海労金、近畿労金、TRE、ジャックス、CCCIF、バルセロナ、ブラジルなど
- TOP INTERVIEW 構造改革の成果を土台に、さらに確固たる成長軌道を築く--ジャックス取締役社長CEO兼COO 杉本直栄
- 信販会社 日本信販/オリコ/ジャックス/セントラル/アプラス (特集 2004年度決算詳報)
- ジャックス 4年間ノンストップの高性能システム (特集 基幹システム共同化の勢力地図)