Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
スポンサーリンク
概要
- 論文の詳細を見る
The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors. To define the essential functions of OXTR, we generated mice with a null mutation in the Oxtr gene (Oxtr-/-) and compared them with OXT-deficient (Oxt-/-) mice. Oxtr-/- mice were viable and had no obvious deficits in fertility or reproductive behavior. Oxtr-/- dams exhibited normal parturition but demonstrated defects in lactation and maternal nurturing. Infant Oxtr-/- males emitted fewer ultrasonic vocalizations than wild-type littermates in response to social isolation. Adult Oxtr-/- males also showed deficits in social discrimination and elevated aggressive behavior. Ligand Oxt-/- males from Oxt-/- dams, but not from Oxt+/- dams, showed similar high levels of aggression. These data suggest a developmental role for the OXT/OXTR system in shaping adult aggressive behavior. Our studies demonstrate that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior.
- 2006-12-14
論文 | ランダム
- Anti-VEGF Receptor Antagonist (VGA1155) Reduces Infarction in Rat Permanent Focal Brain Ischemia
- Loss of CO2-induced Distensibility in Cerebral Arteries with Chronic Hypertension or Vasospasm after Subarachnoid Hemorrhage
- Effect of VEGF Receptor Antagonist (VGA1155) on Brain Edema in the Rat Cold Injury Model
- Isolated Oculomotor Nerve Paresis in Anaplastic Astrocytoma With Exophytic Invasion
- Sca-land thy-1 accelerate neuron-like differentiation in bone marrow stromal cells