J022021 フーリエイメージングに基づく機能的0CTを用いた脳機能の3次元マイクロ計測([J02202]診療技術と臨床バイオメカニクス(2))

概要

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Functional optical coherence tomography (functional OCT, fOCT) has been developed as 3-dimensional and micro-scale visualizing technique of brain function. Functional signals are obtained by the changes of OCT signal intensities before and after stimulation. However, it is difficult to provide the brain function due to physiological noises, e.g. heartbeat and respiration, and mechanical artifacts, e.g. intensity fluctuation of light source. In this study, a new fOCT paradigm is proposed by employing Fourier imaging technique, which uses continuous and periodic stimulation and extracts the frequency component at the stimulation to remove periodic noises by Fourier analysis. Proposed technique is applied to cat primary visual cortex in vivo and investigated, comparing with conventional brain imaging, i.e. optical intrinsic signal imaging. As the results, 3-dimensional brain functional map was obtained by fOCT and has high correlation with optical intrinsic signal imaging (R=0.79). Therefore, Fourier imaging based fOCT is promising for 3-dimensional and micro-scale imaging of brain function.
2011-09-11