自己末梢血幹細胞採取におけるアフェレシスの安全管理 : 血液センターが医療施設に出張して採取する場合(<特集>ドナーアフェレシスの安全性)

概要

論文の詳細を見る
Since 1979 we have made a remarkable effort to promote the blood component collection, such as leukocytes and platelets, on healthy donors according to clinical demand. Based on this experience, we have been carrying out 171 peripheral blood stem-cell collections(PBSC:142cases among 99 patients and 29 among 15 healthy family donors),using COBE-SPECTRA as requested by the hematological department of the Kyoto First Red Cross Hospital. Our PBSC procedures at the hospital required almost 2.5〜3.O hr to collect the average 250 ml plasma, which included more than 1 × 10^6 of CD 34 cells/kg, and could be completed in almost all cases. The exceptions were two blood leakage and one obstruction of the drawing tube. On the other hand, we have several times observed various side effects because of PBSC procedures. The most frequent ones were a citrate toxication and minor side effects such as headache, nausea, and general fatigue. In conclusion, we believe that the most important issues for the safety control of PBSC procedure on a patient are an informed consent that does not give a coercive feeling to the patient, a well-trained operation by nurses under the observation of a hematologist, a higher yield of stem cells with a short operation time, and a high-quality validity of the device and disposable kit.
日本アフェレシス学会の論文
2002-10-31