根端メリステム構築を担うRoot meristem growth factor(RGF)(<特集>植物ペプチドシグナル)

概要

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Root meristem growth factor (RGF) is a 13-amino-acid tyrosine-sulfated peptide involved in maintenance of the root stem cell niche in Arabidopsis. RGF was identified in a search for sulfated peptides that recover root meristem defects of the tpst-1 mutant in combination with in silico screening of genes encoding sulfated peptides and practical bioassays using synthetic sulfated peptides. This approach is based on the assumption that the severe short root phenotype of the tpst-1 mutant reflects deficiencies in the biosynthesis of all the functional tyrosine-sulfated peptides. RGFs are produced from ≈ 100-amino-acid precursor peptides via post-translational sulfation and proteolytic processing. RGF family peptides are expressed mainly in the stem cell area and the innermost layer of central columella cells. RGF peptides regulate root development by upregulating PLETHORA transcription factor which are specifically expressed in root meristem and mediate patterning of the root stem cell niche.
2013-05-31