PADと細胞移植(<特集>動脈硬化とアフェレシス)
スポンサーリンク
概要
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Cell therapy using implantation of autologous bone-marrow or peripheral mononuclear cells as well as circulating progenitor cells increases collateral artery formation and improves limb ischemic symptoms in patients with critical limb ischemia (CLI) who have no other treatment option. Unfortunately, the mechanism by which cell therapy induces angiogenesis remains unclear. Interestingly, an improvement of endothelial function is observed in patients with CLI after cell therapy. Cell therapy would provide a new aspect of therapeutic angiogenesis. Future large-scale studies are needed to confirm the effects of cell therapy on the clinical symptoms and cardiovascular outcomes in patients with CLI. In this review, we would like to focus on the background of cell therapy and the safety, feasibility, putative mechanisms, and limitations of cell therapy in patients with CLI.
- 2013-02-28