成長期の骨格性下顎前突症における下顎骨の過大な成長の予測 : 形態学的研究とゲノム解析を用いて
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概要
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Mandibular prognathism is one of the most common facial deformed morphological phenotypes and is called skeletal Class IE malocclusion in orthodontics. It is thought to be a polygenic disorder that results from an interaction between susceptibility genes and environmental factors. Precise prediction about excessive growth of mandible in young mandibular prognathism patients leads to reliability of prognosis of orthodontic treatment. From morphological studies using cephalogram, growing mandibular prognathism patients, who have wide mandibular gonial angle, forward-inclined mandibular ramus, and short cranial base, will frequently show excessive growth of mandible later. For the patients, orthopedic appliances often are not effective against excessive mandibular growth, and then orthognathic surgery will be often necessary for them who grow up. In genomic studies, linkage analyses and association studies have been recently performed for a decade. We performed a genome-wide association study (GWAS) using 23465 microsatellite markers to detect mandibular prognathism susceptibility regions and speculated on two novel suggestive associations on chromosomes 1q32.2 (D1S1358i: P=4.22×10^<-4> and 1p22.3 (D1S0411i: P=6.66×10^<-4>. D1S1358i was located on chromosome 1q32.2 and was an intron of the PLXNA2 (plexin A2) gene. D1S0411i was located on chromosome 1p22.3 and was approximately 23 kb upstream of the SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein) gene. The fusion of morphological studies and genomic studies will develop custom-made orthodontic treatment in growing mandibular prognathism patients.
- 2012-12-06