Gene module detection from the conservation of gene coexpression patterns among species

概要

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Gene module is one of the most effective information to understand gene functions. Since it is difficult to detect reliable module information with high coverage of genes, many wet researchers have worked hard to detect gene modules. One of widely used methods is based on gene coexpression. Gene coexpression is useful to find related genes from the query gene, but gene coexpression data tend to be noisy. To overcome the noise problem of the gene coexpression, we propose a new method to detect gene module based on conservation of gene coexpression among different species. As a result, we could detect 100 gene modules without any prior knowledge, and some of them were well-characterized modules. For example, the largest module we detected was the ribosomal protein module, which is known to form a large protein complex. We report the results of detected module based on the gene coexpression conservations.
2013-03-14