同種造血幹細胞移植後ウイルス感染に対するドナーリンパ球を用いた養子免疫療法(<特集>ドナーアフェレシスの現状と展開)

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概要

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• Viral infection has remained one of the primary factors causing morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The reconstitution of virus-specific T cells is considered to be indispensable to control viral infection after allogeneic HSCT. Although donor lymphocyte infusion (DLI) might improve viral infection, there is a possibility that DLI causes graft-versus-host disease (GVHD) and marrow suppression. Virus-specific T cells have been expected to cure persistent viral infection without GVHD, and clinical trials have shown the safety and efficacy of adoptive transfer of virus-specific T cells for prophylaxis and treatment of viral infections such as cytomegalovirus and Epstein-Barr virus. However, the number of patients who received adoptive immunotherapy has been limited, because time and special institutions are required to generate virus-specific T cells. In Western countries, Cell Banks have been established so that virus-specific T cells are available off the shelf.

• 2012-10-31

著者

• 西田 徹也

  名古屋大学医学部附属病院血液内科

関連論文

• 同種造血幹細胞移植後ウイルス感染に対するドナーリンパ球を用いた養子免疫療法(ドナーアフェレシスの現状と展開)

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