Study of the Chromium Metabolism and Speciation in Diabetic Rats by Enriched Stable Isotopic Tracer Technique Combined with Neutron Activation Analysis
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概要
- 論文の詳細を見る
Trivalent chromium (Cr III) has been known as a potentiator to insulin in mammal glucose and lipid metabolism. However, the chromium (III) metabolism and speciation in organisms is still not well known because of its ultra low content exist. In order to study the metabolism of Cr (III) in diabetics, the distribution patterns of chromium in the liver, kidney, pancreas, testes as well as in the organic subcellular fractions of the alloxan-diabetic rats were studied by the enriched stable isotope ^<50>Cr^<3+> tracer technique combined with neutron activation analysis (NAA). Further, the chromium-containing proteins in the liver cytosol, serum and urine of the normal and diabetic rat were investigated. After a single intravenous injection of enriched stable isotope Cr-50 tracer solution, the Sephadex G-25 gel chromatography combined with NAA was used to isolate and characterize protein-bound chromium in the above materials.
- 放射化分析研究会の論文
著者
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Chai Z.
Key Laboratory Of Nuclear Analytical Techniques Institute Of High Energy Physics Chinese Academy Of Sciences
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Feng W.
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences
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Ding W.
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences
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Qian Q.
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences
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Ding W.
Key Laboratory Of Nuclear Analytical Techniques Institute Of High Energy Physics Chinese Academy Of Sciences
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Feng W.
Key Laboratory Of Nuclear Analytical Techniques Institute Of High Energy Physics Chinese Academy Of Sciences
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Qian Q.
Key Laboratory Of Nuclear Analytical Techniques Institute Of High Energy Physics Chinese Academy Of Sciences