Inference of target gene regulation via miRNAs during cell senescence by MiRaGE Server

概要

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MiRNAs are recently known to be critical players causing cell senescence, by regulating target genes. Thus inference of miRNAs critically regulating target genes is important. However, miRNAs critically regulating target genes are believed to have significant fold changes, typically upregulations, during cell senescence. In this study, we consider the target gene regulation by miRNAs together with miRNAs expression change during fibroblast IMR90 cell senescence. Then we found that the simultaneous consideration of two criterion lists more feasible miRNAs: i.e., miRNAs being more often reported to be down/upregulated and/or having biological backgrounds inducing cell senescence. Thus, the amount of target gene regulation, which can be inferred by the recently developed MiRaGE Server, is recommended to be considered together for the estimation of miRNAs critically contributing to cell senescence.
2012-03-21