Tissue specific methylation and genotype
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概要
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It is unclear how genotype affects methylation. In this paper, we have applied principal component analysis to both genotype and methylation on tumor, adjacent normal tissue, and blood DNA from 30 patients. Dominant pattern turns out to be upregulation from blood to tumor through tissued for both genotype and methylation. Overlap between significantly upregulating genotype and methylized genes are significantly overlaped. Thus, at least, for some regions, genotype correlates to methylation.
- 2011-06-16
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