MNM-1A-4 マイクロ構造化表面を利用した接着性細胞フィルタリング基質の開発(セッション 1A マイクロ・ナノスケールバイオ計測と医用応用)

概要

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Cell migration control techniques are important for medical and biological engineering, especially in the fields of tissue engineering and cancer diagnosis and treatment. To explore new functions of microstructured substrates, we investigated the transient changes in the behavior of highly migratory cells coming from a flat surface to a microgrooved surface. A single line groove (1.5 μm in width, 20 μm in depth) and intersecting grooves (1.5 μm in width, 20 μm in depth, 5 μm in spacing) repelled the cells effectively. Whereas, wider intersecting grooves (4 μm in width) trapped or repelled the cells. Whether the cell was trapped or repelled depended on cell angle of approach to the boundary with the intersecting grooved surface, which suggests the possibility of motility-based filtering of cells. The microstructured surfaces presented here yield a new design concept of sophisticated cell culture substrate.
一般社団法人日本機械学会の論文
2010-10-12